Translational efficacy biomarkers
Drug discovery projects are massively speeded up if a biochemical efficacy biomarker is available: Target response can be followed from cell culture over animal to man.
The method of choice for metabolic markers is LC/MS – often hardly available and disregarded at discovery level, but readily available from 3rd party labs. I have extensive experience with many markers (see list). Let me help to bridge this gap.
DMPK and ADME analytics
LC/MS has become the most important analytical method in DMPK assessment due to its capabilities in both quantitative and qualitative analysis. The choice of the suitable MS technology is pivotal for meaningful results.
Our experience with both kinetic, enzymological and metabolic studies for drug discovery qualifies us for research partnerships in your projects.
Mass spectrometric assay readouts
Mass spectrometry allows sensitive multiplex detection of metabolic assay readouts at limited throughput. Ideally suited for mechanistic studies and/or selectivity assays and counterscreens.
Once a method is established it will also serve as translational target response biomarker.
Preclinical - clinical project management
Together with our safety and clinical partner PKI we manage preclinical projects for startup companies. In this connection PKI takes care for the later stages and regulatory aspects and smv3 contributes discovery and analytical competence.
We assess your project portfolio and come up with a gap analysis. If desired we plan and manage the completion of missing data.
Technology advice in drug discovery
A plethora of technologies and methods are evolving to support drug discovery. All of them have advantages and drawbacks and not always both are clearly stated. A closer look is advised before introducing ‘breakthrough technologies’.
Mass Spectrometry expertise
Mass spectrometry and LC/MS play a pivotal role in drug discovery . My expertise covers most pharma research applications and I can support you with advice, courses, coaching and outsourcing.
 Read on the analytics page what LCMS can contribute in drug discovery.
Your project has a specific issue? You heard about an attractive new technology? Contact me for a first discussion and subsequent steps will be made after a CDA is established.
Since more than 20 years I give lectures at the school of pharmacy of the University of Basel. The topics focus on purpose oriented method choice and instrumental analytical methods in drug discovery in general.
Link to our Bachelor lecture, Master lecture at the Uni Basel, or visit our lecture copanion website at unibas.smv3.ch
Refresher courses on demand
Hire us for practise oriented refresher or beginner courses for quantitative HPLC, GC/MS, LC/MS and advanced MS methods.
Our infrastructure supports fully virtualized courses with video support, web based data exchange of larger data amounts and e-assessment, respecting the most conservative requirements of data privacy.
Web and Design
Illustrations for Life Sciences
Biotech and pharma startups need webmasters and graphic designers who are not only multilingual but also speak the ‘life science language’ and understand the complex relationships in biology, technology and life. My experience in drug discovery, my graphical talent and my language and informatics skills make me a suitable creator for your publication.
Read on the graphics page what matters in scientific communication.